Vines can threaten trees by competing for resources, girdling trunks, and creating entry points for disease. The right vine killer should target the growth without harming the tree itself. The products below are aimed at stopping unwanted woody vines and stumps, while remaining safe for surrounding landscapes when used as directed. This guide highlights five reliable options that address both live vines and stump sprouts, plus a practical buying guide to help you choose the right formula for your yard.
| Product | Brand | Use | Notes |
|---|---|---|---|
| Stump-Out Stump & Vine Killer | Bonide | Vines, broadleaf weeds; stump killer | 8 oz concentrate with applicator |
| Vine & Stump Killer With Applicator | Bonide | Kills tough vines, brush; stump control | 2-pack |
| Tordon RTU Specialty Herbicide | Dow AgroSciences | Kills woody plants and trees on non-cropland areas | Not for sale in several states |
| Pulverize Weed, Brush, and Vine Killer | Pulverize | Fast-acting vine and weed control | Safe for hardscapes |
| Southern Ag Brush Killer | Southern Ag | Vines and stump sprouts | 1 gallon |
Stump-Out Stump & Vine Killer – Bonide

Bonide’s Stump-Out is formulated to stop undesirable woody vines and broadleaf weeds while also serving as a stump killer when undiluted. The product can be applied as a foliar spray using a hose-end or tank sprayer, offering flexibility for different site conditions. This multi-use approach can simplify management by combining vine control with stump treatment in a single product. The concentrate form requires careful dilution according to label directions to achieve optimal results. It is designed for safe application around landscaping when used as directed.
Vine & Stump Killer With Applicator – Bonide

This Bonide option emphasizes killing tough vines, brush, suckers, and more. The included applicator makes it easier to target cut stumps and freshly cut surfaces, reducing the chance of resprouting. The product is sold as a convenient 8-ounce concentrate and is marketed as a value 2-pack, offering cost efficiency for larger sites. Proper use involves painting or applying to target areas with care to avoid non-target plants. It is designed for quick uptake and practical spray-on use in landscape settings.
Tordon RTU Specialty Herbicide

Tordon RTU is a looking-for-woody-plant-control solution designed for cut surfaces and non-cropland areas like fence lines and rights-of-way. It translocates through the root system to suppress resprouts across multiple woody species. The product is not available in every state and effectiveness depends on site conditions and proper application on exposed cut surfaces. This option is positioned for professionals managing larger properties where woody vegetation control is a priority, with attention to regulatory restrictions in certain regions.
Pulverize Vine, Brush & Weed Killer – 32 oz

This fast-acting formula targets weeds, brush, and vines year-round. With active ingredients including ammoniated soap of fatty acids and maleic hydrazide, it aims to extinguish poison ivy, poison oak, and other unwanted vegetation. The non-staining formula is designed for outdoor surfaces like concrete and pavement, making it suitable near hardscapes without leaving residue. It is a convenient option for lawns, trails, and landscapes where precise targeted application is desired.
Southern Ag Brush Killer – 1 Gallon

Southern Ag Brush Killer is formulated for vines and brush control, with a gallon size that suits larger properties or multiple applications. This product targets stubborn growth around trees and fence lines, helping to reduce resprouts. The concentrate approach means you’ll mix with water per label directions. As with other herbicides, effectiveness depends on timing, weather, and correct application on the intended vegetation, while minimizing exposure to desirable plants and soil life.
Bonide Vine Stump Killer with Applicator (Pack of 5)

Bonide’s five-pack provides a ready-to-use approach for multiple sites or recurring treatments. This product focuses on killing vines and stumps with fast uptake and deep action for complete control of unwanted growth above and below ground. As a pack, it supports ongoing management where vines tend to re-emerge after pruning, reducing the need for frequent re-application. Always follow label directions and observe safety precautions to protect nearby plants and soil quality.
Buying Guide: Key Purchase Considerations
- Targeted vs. broad control: For trees, prioritizing products that effectively stop vine growth and suppress stump sprouting minimizes damage to the tree while preventing re-growth.
- Application method: Consider whether you need a hose-end spray, brush-on applicator, or concentrated formula with mixing. Applicators can improve precision around tree trunks.
- Site and vegetation: Some products are designed for non-cropland areas or specific woody species. Check label compatibility with your location and target plants.
- Uptake and translocation: Products that translocate into the root system often deliver longer-lasting results, reducing resprouts.
- Safety and labeling: Review state restrictions, especially for products like Tordon RTU. Ensure you follow all safety, disposal, and environmental guidelines.
- Non-target protection: Choose formulations that minimize staining and protect nearby grasses, ornamentals, and soil life during application.
- Size and cost efficiency: Gallon sizes and multi-pack options can offer better value for larger properties, but ensure you have appropriate storage and usage plans to avoid waste.